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用嗜肝病毒动物模型对磷甲酸三钠的抗乙肝病毒作用机理和效果作了初步的研究。18只持续感染鸭乙肝病毒的麻鸭腹腔内隔日注射200～400mg／kg磷甲酸三钠共6周，给药期间分别取血清和肝组织以斑点杂交和Southernblot试验检测乙肝病毒DNA、结果显示：尽管用药过程中血清病毒DNA滴度有一过性下降，但肝内仍显示出活跃的病毒复制。表明磷甲酸三钠的抗乙肝病毒作用机理主要不是在于抑制病毒DNA或RNA聚合酶，而且它的抗乙肝病毒效果也并不理想。
The animal model of hepadnavirus was used to study the mechanism and effect of triclosan against hepatitis B virus (HBV). Twenty-eight ducks infected with duck hepatitis B virus were intraperitoneally injected with 200-400 mg / kg trisodium phosphate for 6 weeks. Serum and liver tissue were taken from the mice during the treatment period to detect hepatitis B virus DNA by dot blot and Southern blot analysis. Despite a transient decrease in serum viral DNA titer during the course of the medication, the virus still showed active viral replication in the liver. The results showed that the mechanism of anti-HBV activity of trisodium Phosphate is not mainly to inhibit viral DNA or RNA polymerase, but also its anti-hepatitis B virus effect is not satisfactory.