目的：探讨肝硬化时肠源性内毒素血症（ＩＥＴＭ）和血浆内皮素（ＥＴ）在肾功能障碍中所起的作用。方法：采用鲎试剂基质显色法定量测定内毒素，用放射免疫法测定ＥＴ，常规生化法测定血肌酐，同时留２４小时尿液测定尿肌酐与尿钠。采用复合病因复制肝硬化模型。结果：肝硬化患者血浆内毒素水平随肝硬化病变加重而升高，内毒素水平在肝硬化伴功能性肾衰患者中（２０６±１５１ＥＵ／ｍＬ）明显高于肝硬化代偿期（０３２±０２０ＥＵ／ｍＬ）与失代偿期伴腹水（０７３±０２９ＥＵ／ｍＬ），并与肌酐清除率（ＣｒＣｌ），尿钠排泄呈负相关。肝硬化鼠血浆内毒素与肾组织ＥＴ含量（分别０２８±００４ＥＵ／ｍＬ，４６２±０７９ｎｇ／ｇ）明显高于对照组（分别０１４±００２ＥＵ／ｍＬ，２４８±１８８ｎｇ／ｇ），两者呈正相关。结论：ＩＥＴＭ在诱发象征肝功衰竭的ＦＲＦ中起重要作用；ＩＥＴＭ对肾组织ＥＴ的生成和释放有一定作用 Objective: To investigate the role of IETM and ET in renal dysfunction during cirrhosis. Methods: Quantitative determination of endotoxin by 鲎 reagent matrix colorimetric assay, ET by radioimmunoassay, serum creatinine by routine biochemical method, urinary creatinine and urinary sodium for 24 hours. The complex etiology of liver cirrhosis model. Results: The level of plasma endotoxin in cirrhotic patients increased with the severity of cirrhosis. The level of endotoxin in cirrhotic patients with functional renal failure (206 ± 151EU / mL) was significantly higher than that in decompensated liver cirrhosis (032 ± 020EU / mL) and decompensated ascites (073 ± 029EU / mL), and was negatively correlated with creatinine clearance (CrCl) and urinary sodium excretion. The levels of plasma endotoxin and renal tissue ET in cirrhotic rats were significantly higher than those in the control group (014 ± 002EU / mL, 028 ± 004EU / mL, 462 ± 079ng / g, respectively) 2  48 ± 1  88 ng / g), both were positively correlated. CONCLUSIONS: IETM plays an important role in inducing FRF, a marker of hepatic failure, and IETM has a role in the production and release of ET in renal tissue