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目的:探讨黄芪多糖对乙型肝炎相关的肝脏脂肪变性的治疗作用及机制。方法:选取5-6周龄的SPF雄性小鼠共20只作为研究对象,随机分为研究组和对照组,各10例,研究组小鼠进行黄芪多糖溶液灌胃,对照组小鼠采用同样剂量的生理盐水灌胃。分别于用药前后测量体重(BW)、甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)。结果:研究组小鼠用药后BW和TG明显低于对照组,数据经统计学比较具有显著差异(P<0.05)。用药前两组小鼠ALT和AST比较无显著差异,用药后研究组ALT和AST明显下降,与对照组用药后比较具有显著差异(P<0.05)。结论:黄芪多糖可有效降低乙型肝炎小鼠BW和血脂TG,减少ALT和AST,促进肝脏的排毒与修复,从而改善肝脏脂肪变性,缓解和治疗HBV的毒性和侵害性,提高治疗效果。
Objective: To investigate the therapeutic effect of astragalus polysaccharides on hepatic steatosis associated with hepatitis B and its mechanism. Methods: A total of 20 SPF male mice aged 5-6 weeks were selected as study subjects and randomly divided into study group and control group, with 10 cases in each group. Mice in study group were given gavage with APS, while mice in control group were treated with the same The dose of saline gavage. Body weight (BW), triglyceride (TG), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured before and after treatment. Results: The BW and TG in the study group were significantly lower than those in the control group after treatment. The data showed significant differences (P <0.05). There was no significant difference between the two groups before treatment ALT and AST, the study group after treatment ALT and AST decreased significantly compared with the control group after treatment was significantly different (P <0.05). Conclusion: Astragalus polysaccharides can effectively reduce the BW and TG in mice with hepatitis B, decrease ALT and AST, promote the detoxification and repair of the liver, improve the fatty degeneration of the liver, relieve and treat the toxicity and invasiveness of HBV, and improve the therapeutic effect.