本发明提供了一种高纯度2-(3-醛基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸乙酯的合成方法,以对氰基苯酚、硫代乙酰胺为起始原料,经硫酰化反应得到4-羟基硫代苯甲酰胺(II),反应产物不分离直接进行噻唑化反应,分离得到2-(4-羟基苯基)-4-甲基-5-噻唑甲酸乙酯(III);将式(III)化合物经甲酰化反应得2-(3-甲醛基-4-羟基苯基)-4-甲 The invention provides a method for synthesizing ethyl 2- (3-aldehyde-4-isobutyloxyphenyl) -4-methylthiazole-5-carboxylate with high purity and p-cyanophenol, Amide as the starting material to obtain 4-hydroxythiobenzamide (II) through sulfonylation reaction, and the reaction product is directly subjected to thiazolization reaction without isolation to obtain 2- (4-hydroxyphenyl) -4-methyl Thiazole carboxylic acid ethyl ester (III); the compound of formula (III) is formylated to give 2- (3-carboxaldehyde-4-hydroxyphenyl)