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[目的]了解埃可病毒6型(ECHO6)所致无菌性脑膜炎暴发流行后长汀县≤15岁健康儿童以及非流行区健康儿童的中和抗体水平。[方法]采集流行区和非流行区健康儿童血清,用微量板法测定血清中和抗体水平。[结果]流行区(长汀县)≤15岁健康儿童中和抗体GMT为1∶62.17,显著高于非流行区(漳平市)的GMT(1∶10.72);流行区中和抗体阳性率为36.74%,非流行区阳性率为5.60%;ECHO6在各年龄组间感染情况无显著差异(P>0.05)。[结论]ECHO6所致疾病流行后,人群具有较高的免疫力。
[Objective] To understand the neutralizing antibody level of healthy children aged ≤15 years old and non-endemic healthy children in Changting County after the eruption of aseptic meningitis caused by ECHO6. [Methods] Serum samples of healthy children in epidemic area and non-endemic area were collected. The level of serum neutralizing antibody was measured by microplate method. [Results] The GMT of neutralizing antibody in prevalence area (Changting County) ≤15 years old children was 1:62.17, which was significantly higher than GMT (1:10.72) in non-endemic area (Zhangping City). The positive rate of neutralizing antibody in epidemic area was 36.74% in non-endemic areas, and 5.60% in non-endemic areas. There was no significant difference in infection of ECHO6 among all age groups (P> 0.05). [Conclusion] The crowd has high immunity after the disease caused by ECHO6.