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目的：分析局部应用米诺环素软膏与局部应用甲硝唑凝胶治疗牙周炎的临床效果。方法以我院口腔门诊收治的110例慢性牙周炎患者为例，使用随机的方法将110例患者分为对照组和观察组各55例，对照组采用局部应用甲硝唑凝胶治疗，观察组患者予以局部应用米诺环素软膏治疗，对比两组患者的治疗结果。结果观察组的治疗有效率及不良反应发生率优于对照组，P＜0.05；治疗后观察组的牙菌斑指数（PLT）、牙周袋深度（PD）、龈沟出血指数（SBI）、牙龈指数（GI）等牙周指标均优于对照组，两组间差异明显，P＜0.05。结论在牙周炎的治疗中应用米诺环素软膏局部治疗的效果优于甲硝唑凝胶，能够更好的改善患者的牙周指标，且不良反应少，值得临床推广。“,”ObjectiveTo analyze the clinical effect of topical application of minocycline ointment and topical metronidazole gel in the treatment of periodontitis.MethodsOne hundred and ten patients with chronic periodontitis were divided into two groups: the control group and the observation group (55 cases). The control group was treated with metronidazole gel, Patients in the observation group were treated with minocycline ointment topically and the results were compared between the two groups.ResultsThe effective rate of treatment and the incidence of adverse reactions were better in the observation group than those in the control group (P <0.05). After treatment, the plaque index (PLT), depth of periodontal pocket (PD), sulcus bleeding index (SBI) Gingival index (GI) and other periodontal indicators were better than the control group, the difference between the two groups was significant,P<0.05. ConclusionMinocycline ointment is superior to metronidazole gel in the treatment of periodontitis. It can improve the periodontal index of the patients and has less adverse reactions. It is worthy to be popularized.