奥美拉唑对胃粘膜有阻断H~+、K~+-ATP 酶的作用,从而抑制胃酸分泌。本文对13个国家45个医疗中心的602例良性胃溃疡及幽门管溃疡患者用奥美拉唑(20mg,每日1次,203例;或40mg,每日1次,194例)与用雷尼替丁(150mg,每日2次,205例)对促进溃疡愈合及停药后6个月随访溃疡复发率作了比较。溃疡愈合率:4周时奥美拉唑40mg为80%,20mg为69%,雷尼替丁150mg为59%;8周时分别为96、89和85%。经过多项分析证实,服用奥美拉唑4周内愈合的溃 Omeprazole gastric mucosal block H ~ +, K ~ + -ATP enzyme role, thereby inhibiting gastric acid secretion. In this paper, 602 patients with benign gastric ulcer and pyloric ulcer in 45 medical centers in 13 countries were treated with omeprazole (20 mg once daily, 203 cases, or 40 mg once daily, 194 cases) Niitidine (150mg twice daily, 205 cases) to promote ulcer healing and stopping 6 months follow-up ulcer recurrence rates were compared. Rate of ulcer healing: Omeprazole 40 mg was 80% at 4 weeks, 69% at 20 mg and 59% at ranitidine 150 mg; 96, 89, and 85% at 8 weeks, respectively. After a number of analyzes confirmed that the omeprazole healing collapse within 4 weeks