临床常见骨质疏松中,有8％—15％的并非由于缺钙、维生素D或疾病引起,而是药物所致体内矿物质代谢紊乱所致。资料表明,下列药物可致骨质疏松症。 糖皮质激素 最早报道见于1950年,是目前最常见的药源性骨质疏松症的因素。糖皮质激素可促进蛋白质分解,增加钙磷排泄,减少蛋白质粘多糖的合成,使骨基质形成障碍;糖皮质激素还可抑制成骨细胞活性,具有抗维生素D活性作用;长期使用糖皮质激素便易出现骨质疏松、骨小梁和成骨细胞减少。这类药源性骨质疏松症除表现为腰背痛外,还是老年人自发性骨折的重要因素之一。国外资料报道,长 Clinical common osteoporosis, 8% -15% is not due to calcium deficiency, vitamin D or disease caused, but due to drug-induced metabolic disorder caused by minerals in the body. The data show that the following drugs can cause osteoporosis. Glucocorticoid was first reported in 1950, is the most common drug-induced osteoporosis factors. Glucocorticoids can promote protein decomposition, increase calcium and phosphorus excretion, reduce the synthesis of mucopolysaccharide protein, the formation of barriers to bone matrix; glucocorticoid can inhibit osteoblast activity, with anti-vitamin D activity; long-term use of glucocorticoid Easy to appear osteoporosis, trabecular and osteoblastic reduction. Such drug-induced osteoporosis in addition to the performance of low back pain, or the elderly is an important factor in spontaneous fractures. Foreign information reports, long