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目的：探讨一氧化氮与脂质过氧化反应在角膜碱烧伤中的作用。方法：在兔右眼角膜用２ｍｏｌ／ＬＮａＯＨ溶液烧伤６０秒钟后，分别于第１、４、８、１６、３２及６４天测量其ＮＯ和丙二醛（ＭＤＡ）的含量及ＳＯＤ活性，左眼为正常对照。结果：烧伤后的第１、４、８、１６及３２天，其ＮＯ和ＭＤＡ含量显著高于对照组，至第６４天接近对照组水平。烧伤后第１～１６天，ＳＯＤ活性较对照组显著降低，第３２天已基本恢复至对照组水平。结论：角膜碱烧伤后角膜组织中ＮＯ水平升高和脂质过氧化反应增强可能是其损伤机制之一。
Objective: To investigate the role of nitric oxide and lipid peroxidation in corneal alkali burn. Methods: The contents of NO and malondialdehyde (MDA) and the activity of SOD were measured on the 1st, 4th, 8th, 16th, 32nd and 64th days after the cornea was burned in 2 mol / L NaOH solution for 60 seconds. Eye as a normal control. Results: The NO and MDA contents in the 1st, 4th, 8th, 16th and 32nd days after burn were significantly higher than those in the control group, reaching the level of the control group on the 64th day. From the 1st to 16th day after burn, SOD activity was significantly lower than that of the control group and recovered to the control level on the 32nd day. Conclusion: The corneal alkali burns corneal NO levels and lipid peroxidation increased may be one of its mechanisms of injury.