多项动物实验和临床实验已经充分证实,抗血管生成疗法可以抑制肿瘤生长。在可抑制肿瘤生长的分子中,许多是蛋白与多肽,包括细胞因子、趋化因子、血管内皮生长因子及其受体的抗体、可溶性受体、胞外基质蛋白片段及小分子合成多肽等。简要综述其中部分分子的作用机理及临床应用情况。 A number of animal experiments and clinical trials have fully confirmed that anti-angiogenic therapy can inhibit tumor growth. Among the molecules that can inhibit tumor growth, many are proteins and polypeptides, including cytokines, chemokines, antibodies to vascular endothelial growth factor and its receptors, soluble receptors, extracellular matrix protein fragments and small molecule synthetic peptides. A brief review of some of the molecular mechanism of action and clinical application.