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First total synthesis of saurufuran B 1, a furanoditerpene, from (E, E)-farnesol 2 and citraconic anhydride 3 through thirteen steps is described. Our work involves two key steps: (1) High regioselective alkylation of 2-(tert-butyldimethylsiloxy)-4-methylfuran 6 with allylic iodides 5 in the presence of silver trifluoroacetate1 and (2) Conversion of substituted γ-lactone 7 into furan derivative 82.
First total synthesis of saurufuran B 1, a furanoditerpene, from (E, E) -farnesol 2 and citraconic anhydride 3 through thirteen steps is described. Our work involves two key steps: (1) High regioselective alkylation of 2- (tert-butyldimethylsiloxy) ) -4-methylfuran 6 with allylic iodides 5 in the presence of silver trifluoroacetate 1 and (2) Conversion of substituted γ-lactone 7 into furan derivative 82.