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目的:评价紫杉醇联合顺铂对晚期乳腺癌的治疗作用。方法:对我院60例晚期乳腺癌患者进行化疗,方案为紫杉醇l35mg/m2,dl,静滴3h,顺铂14~20mg/m2,dl~d5,静滴,每4周重复。结果:60例完成疗效观察,RR68%(41例),CR18例(30%),PR38%(23例)。主要毒副作用为骨髓抑制。7例(11.7%)出现Ⅲ度白细胞下降,无Ⅳ度发生。结论:紫杉醇加顺铂治疗晚期乳腺癌有较高的临床疗效,较低的不良反应,可作为治疗晚期乳腺癌的首选方案。
Objective: To evaluate the therapeutic effect of paclitaxel plus cisplatin on advanced breast cancer. Methods: 60 cases of advanced breast cancer patients in our hospital for chemotherapy, the program for the paclitaxel l35mg / m2, dl, intravenous infusion of 3h, cisplatin 14 ~ 20mg / m2, dl ~ d5, intravenous infusion, repeated every 4 weeks. Results: 60 cases completed the observation of efficacy, RR68% (41 cases), CR18 cases (30%) and PR38% (23 cases). The main side effects of bone marrow suppression. 7 cases (11.7%) Ⅲ grade leukopenia, no Ⅳ degree occurred. Conclusion: Paclitaxel and cisplatin in the treatment of advanced breast cancer have higher clinical efficacy and lower adverse reactions, which may be the first choice for the treatment of advanced breast cancer.