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Objective:To evaluate Ihe clinical effect of transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy on patients with local advanced pancreatic cancer.Methods:Fifty-one patients with Jocal advanced pancreatic cancer from June 2002 to February 2004 were enrolled.twenty-four patients of combined group were treared with transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy.while twenty-seven patients of control group were treated only with transarterial infusion chemotherapy of gemcitabine.Results:There were significant statistical differences between two groupsin clinical benefil response(91.7%versus 74.1%,P＜0.01)and overall remission rate(70.8%versus 33.3%,P＜0.01).The 6-month survival rate,12-month survival rate and 24-month survival rate of combined group were 83.3%,62.5%and 37.5%respectively,while that of control group were 55.6%,33.3%and 11.1% respectively.This showed significant difierence between the two qroups.Conclusion:Transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy may be better than single transarterial infusion chemotherapy of gemcitabine in improving survival rates and elongating survival time of patients with local advanced pancreatic cancer.