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基本原理:特发性肺动脉高压(idiopathic pulmonary arterial hypertension,IPAH)以肺动脉平滑肌细胞(pul monary artery smooth muscle cell,paSMC)增生导致肺动脉中层肥厚为特征。通常认为炎症在IPAH相关的血管重塑中有一定的作用。现已逐渐认识到白细胞介素13(interleukin13,IL-13)是一种组织重塑的调
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by hyperplasia of the pulmonary arteries by pulmonary smooth muscle cells (PASMCs). It is generally accepted that inflammation plays a role in IPAH-related vascular remodeling. It has been gradually recognized that interleukin 13 (IL-13) is a kind of tissue remodeling