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一种凝胶控释的胃内漂浮给药系统(Hydro-dynamically Balanced System)简称HBS.HBS 制剂主要由一种或数种亲水性高分子材料与活性物质组合两成.当口服后与胃液接触时,由于比重小而漂浮于胃液之上,随即制剂表面开始形成凝胶层.该凝胶层能控制水分向制剂渗入并控制药物溶出。而随着凝胶层的溶解使药物连续释出,其释药模式常处于零级与一级之间。当胃中食物开始排空时,制剂不可能同时排出,从而延长了制剂在
A gel controlled release gastric floating delivery system (Hydro-dynamically Balanced System) referred to as HBS.HBS formulations mainly by one or several hydrophilic polymer materials and active substances combined into two.When oral and gastric juice When in contact, it flies above the gastric juice due to its small specific gravity and immediately begins to form a gel layer on the surface of the preparation which controls the penetration of moisture into the formulation and controls the dissolution of the drug. With the dissolution of the gel layer to the continuous release of drugs, the release mode often in between zero and one. When the stomach began to empty the food, the formulation can not be discharged at the same time, thus prolonging the formulation in