为了探索天然产物Cedarmycins衍生物的结构与活性关系,以α-亚甲基-β-羟甲基-γ-丁内酯为起始原料,经过与不同取代的羧酸缩合,合成了19个新的(4-亚甲基-5-羰基-3-四氢呋喃基)-苯甲酸甲酯衍生物。杀菌活性测定结果表明,该类衍生物具有广谱的杀菌活性,尤其对水稻纹枯病菌Rhizoctonia solani和辣椒疫霉Phytophthora capsici显示出很强的杀菌活性,其中化合物2e(R=2,4-2Cl)对这2种病菌的EC50值约为1.6 mg/L。 In order to explore the relationship between the structure and activity of the natural product Cedarmycins derivatives, 19 new compounds were synthesized by condensation with different substituted carboxylic acids starting from α-methylene-β-hydroxymethyl-γ-butyrolactone (4-methylene-5-carbonyl-3-tetrahydrofuranyl) -benzoic acid methyl ester derivative. The bactericidal activity assay showed that the derivatives have broad spectrum bactericidal activity, especially against Rhizoctonia solani and Phytophthora capsici. Among them, compound 2e (R = 2,4- 2Cl) had an EC50 of about 1.6 mg / L against these two pathogens.