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按理论推测西咪替丁可能增加氟尿嘧啶的生物利用度,这种可能性已进行研究。氟尿嘧啶治疗前用西咪替丁对其药物动力学的影响已在15名癌症急患者中进行研
The speculation that cimetidine may increase the bioavailability of fluorouracil has been investigated. The effect of cimetidine on its pharmacokinetics before fluorouracil treatment has been studied in 15 cancer patients