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目的 :报告 3例原发性骨淋巴瘤病例并复习国内外相关文献。方法 :化疗和放疗治疗3例原发性骨淋巴瘤患者。结果 :3例患者均对化疗、放疗敏感 ,并得到完全缓解。结论 :原发性骨淋巴瘤以 B细胞型非霍奇金淋巴瘤多见 ,可侵犯到骨的任何部位 ,通常为局限的溶骨性破坏。 PL B细胞存在 t(3;2 2 ) (q2 7;q11)染色体易位以及 bcl- 2、bcl- 6和 p5 3分子高表达 ,在 PL B病理过程中可能发挥重要作用。
OBJECTIVE: To report three cases of primary bone lymphoma and to review relevant literature at home and abroad. Methods: Chemotherapy and radiotherapy for 3 patients with primary bone lymphoma. Results: All 3 patients were sensitive to chemotherapy and radiotherapy and were completely relieved. CONCLUSIONS: Primary bone lymphoma is more common with B-cell non-Hodgkin’s lymphoma and can invade any part of the bone, often limiting osteolytic destruction. The presence of t (3; 2 2) (q2 7; q11) chromosomal translocation and the high expression of bcl-2, bcl-6 and p5 3 molecules in PL B cells may play an important role in the pathological process of PL B.