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有机合成,这个多年来在有机化学中一直保持着的研究重点,在1980年也并未改变。有人甚至认为,这一优势变得更强了,而纯粹的反应机理研究则仍处于“守势”。现今反应机理研究的主要兴趣仍然只是希望它能有助于解决合成中的问题, 当然对合成反应的要求也更高了。现在已不仅是要尽可能正确地控制立体化学,人们还希望把这种立体控制用于开链化合物的反应——这一目的在几年前还认为是不可能达到的。近年来这方面有了大量的报导,因此也出现了长篇的综述[Bartlett,P.A.;Tetrahedron,36,2(1980)].Bartlett认为对合成大环内酯和离子透过载体抗菌素(Ionophor)的研究产生了越来越大的兴趣,就是针对这个问题的。本文仍然很感兴趣的一个反应是古老的醇酮加
Organic synthesis, the focus of research that has been held in organic chemistry for many years, has not changed in 1980. Some people even think that this advantage has become stronger, while the study of pure reaction mechanism is still in a “defensive.” The main interest in current research on the reaction mechanism is still only hope that it will help to solve the problem of synthesis, of course, the demand for the synthesis reaction is also higher. It is now not only the control of stereochemistry that is as accurate as possible, but one also wishes to apply this stereoscopic control to the reaction of open-chain compounds - a goal that was not considered possible years ago. Bartlett, PA; Tetrahedron, 36, 2 (1980)]. Bartlett argues that for the synthesis of macrolides and ionophores through the carrier, Ionophor, The growing interest in research has been directed at this problem. One of the reactions that are still of interest to this article is the old alcohol ketones