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对柴油机排出的颗粒物（ＤＥＰ）诱发小鼠骨髓细胞微核进行了研究，结果表明柴油机排出颗粒物（ＤＥＰ）在体内可产生明显的毒性作用。其提取物的剂量在８０－４００ｍｇ／ｋｇ之间，微核率由９．２‰升至３４．７‰，呈现明显的剂量－反应关系。各实验剂量组与对照组比较，均具极显著性差异（Ｐ＜０．０１）。这种遗传毒性作用可能是造成该颗粒致癌性和致突变性的机制之一
The micronuclei of mouse bone marrow cells induced by diesel particulate matter (DEP) were studied. The results showed that diesel particulate matter (DEP) could produce significant toxic effects in vivo. The dose of the extract was between 80-400mg / kg and the micronucleus rate rose from 9.2% to 34.7%, showing a significant dose-response relationship. The experimental dose group compared with the control group, were significantly different (P <0.01). This genotoxic effect may be one of the mechanisms responsible for the carcinogenicity and mutagenicity of this particle