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目的:观察银花解毒汤联合炎琥宁雾化治疗单疱疹病毒性角膜炎的临床疗效。方法:选取60例(85只眼)确诊为单疱疹病毒性角膜炎的患者,随机分为对照组和治疗组各30例,治疗组30例(41眼)采用银花解毒汤联合炎琥宁雾化治疗,对照组30例(44眼)采用炎琥宁雾化联合抗病毒眼药水治疗,每日在裂隙灯下观察病情变化,根据病情连续用药8~18天,随访3个月。对两组患者疗效、治疗时间及复发率进行比较。结果:治疗组患者总有效率高于对照组,组间比较差异有统计学意义(P<0.05);治疗组患者的治疗时间明显短于对照组,组间比较差异有统计学意义(P<0.05);随访3个月,治疗组复发率低于对照组,组间比较差异有统计学意义(P<0.05)。结论:银花解毒汤联合炎琥宁雾化治疗、炎琥宁雾化联合抗病毒眼药水治疗对单疱疹病毒性角膜炎均有良好的疗效,但银花解毒汤联合炎琥宁雾化治疗效果更佳,且复发率低,值得临床推广应用。
Objective: To observe the clinical efficacy of Yinhua Jiedu Decoction combined with Yanhuoning nebulization in the treatment of herpes simplex virus keratitis. Methods: Sixty patients (85 eyes) diagnosed as herpes simplex virus keratitis were randomly divided into control group and treatment group, 30 cases in each group. Thirty patients (41 eyes) in treatment group were treated with Yinhua Jiedu Decoction combined with Yanhuning In the control group, 30 cases (44 eyes) were treated with Yanhuoning nebulization combined with antivirus eye drops. The changes of the disease were observed under the slit lamp daily for 8-18 days according to the condition and followed up for 3 months. The two groups of patients efficacy, treatment time and recurrence rates were compared. Results: The total effective rate in the treatment group was higher than that in the control group, with significant difference between the two groups (P <0.05). The treatment time in the treatment group was significantly shorter than that in the control group, with significant difference between the two groups (P < 0.05). After 3 months of follow-up, the recurrence rate of the treatment group was lower than that of the control group. There was significant difference between the two groups (P <0.05). Conclusion: Yinhua Jiedu Decoction combined with Yanhuoning nebulization, Yanhuoning combined with anti-virus eye drops treatment of herpes simplex virus keratitis have a good effect, but Yinhua Jiedu Decoction combined with Yanhuoning nebulization The effect is better, and the recurrence rate is low, it is worth clinical application.