美国国立癌症研究所Oldham博士(1982年)在肿瘤的免疫治疗基础上首先提出生物反应调节理论,并随后把生物治疗称为继手术,放射,化学治疗之后的肿瘤第四治疗程式,BRM理论认为,在正常情况下,肿瘤与机体防御之间处于动态平衡,肿瘤的发生及增殖与扩散,完全是这种动态平衡失调所致,如果将已经失调的状态人为地调整至正常水平,则可控制肿瘤的生长并使其消退。生物疗法不是以直接攻击肿瘤细胞 Dr. Oldham (1982) of the National Cancer Institute of the United States first proposed the theory of biological response regulation based on the immunotherapy of tumors, and then referred to biological therapy as the fourth treatment program of tumors after surgery, radiation, and chemotherapy. BRM theory believes that Under normal circumstances, there is a dynamic balance between the tumor and the body’s defenses. The occurrence and proliferation and spread of tumors are entirely caused by this imbalance of dynamic balance. If the already misregulated state is artificially adjusted to the normal level, it can be controlled. The tumor grows and causes it to subside. Biological therapy is not to directly attack tumor cells