以荧光光谱法对胸腔内注射国产阿霉素治疗恶性胸腔积液患者的血液、胸水中的药浓度进行监测和药效对比研究。研究表明：胸腔内注射４０ｍｇ阿霉素后，９例患者２ｈ的平均血、胸水药浓度分别为６５ｎｇ／ｍｌ，５９μｇ／ｍｌ，比值为１∶８２９，其它时间的胸水药浓度高于相同时间的血药浓度数百倍（Ｐ＜０．０５）。在１２例的疗效评价中，显效率３３．３％，有效率５０％，未发生骨髓抑制、心肌损害等严重毒副反应。 Fluorescence spectroscopy was used to monitor the concentration of drug in blood and pleural effusion in patients with malignant pleural effusion treated with intrathoracic injection of doxorubicin, and to compare the efficacy of the drug. Studies have shown that after intrapleural injection of 40 mg doxorubicin, the average blood and pleural effusion concentrations in 9 patients at 2 hours were 65 ng/ml and 59 μg/ml, respectively, and the ratio was 1:829. The pleural fluid concentrations at other times were higher than those at the same time. The blood drug concentration was several hundred times (P<0.05). In the evaluation of efficacy of 12 cases, the markedly effective rate was 33.3%, and the effective rate was 50%. No serious side effects such as myelosuppression and myocardial damage were observed.