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紫芝多糖对300拉德照射犬具有一定的预防及较好的治疗作用,并能提高700拉德照射小鼠脾重、脾造血灶及骨髓有核细胞数,促进受亚致死量照射动物造血功能的恢复。该药物的这种作用途径有3种可能,其一是直接或间接地作用于造血干细胞池,增加干细胞数,使照射后存活的干细胞相应增多;其二是降低造血干细胞的辐射敏感性;其三是改善造血微环境,有助于受辐射损伤的干细胞的修复。本文用LACA小鼠骨髓CFU-C(指琼脂培养条件下粒系细胞团生成单位)体外软琼脂双层培养技术对前两种可能性作了初步探讨。
Ganoderma lucidum polysaccharide has a certain degree of prevention and better therapeutic effect on 300 rad irradiation dogs, and can increase the spleen weight, spleen hematopoietic area and bone marrow nucleated cell count of 700 rad irradiation mice, and promote hematopoietic function in sublethal irradiation animals. Recovery. There are 3 possibilities for this action of the drug, one of which is directly or indirectly acting on the hematopoietic stem cell pool, increasing the number of stem cells, correspondingly increasing the number of surviving stem cells after irradiation, and the second is reducing the radiation sensitivity of hematopoietic stem cells; The third is to improve the hematopoietic microenvironment and help repair of stem cells damaged by radiation. In this paper, the first two possibilities were discussed using LAC mouse bone marrow CFU-C (indicating agglutinating granulocyte mass producing unit) in vitro soft agar double-layer culture technique.