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目的探讨奥卡西平(OXC)单药治疗对癫患儿甲状腺激素水平的影响。方法对18例门诊初诊为局限性发作的癫患儿(治疗组)行OXC单药治疗,采集用药前、平均治疗3个月及1a后晨空腹静脉血3mL,用放射免疫法检测其血清四碘甲腺原氨酸(T4)、游离四碘甲腺原氨酸(FT4)、三碘甲腺原氨酸(T3)、游离三碘甲腺原氨酸(FT3)及促甲状腺激素(TSH)水平,并以18例健康儿童作为健康对照组。治疗组与健康对照组性别、年龄无统计学差异。结果OXC治疗前T4、FT4、T3、FT3、TSH与健康对照组比较均无统计学差异(Pa>0.05)。OXC治疗3个月,T4、FT4均比治疗前明显减低,差异均具有高度显著性(Pa<0.01),T3、FT3、TSH与治疗前比较均无统计学差异(Pa>0.05)。OXC治疗1a,T4、FT4与治疗前比较差异均具有高度显著性(Pa<0.01),T3与治疗前比较亦有显著差异(P<0.05),FT3、TSH与治疗前比较无统计学差异(Pa>0.05)。OXC治疗1a,T4、FT4、T3、FT3与治疗3个月相比均无统计学差异(Pa>0.05)。结论OXC长期或短期应用均可影响癫患儿甲状腺激素水平,OXC治疗期间须定期监测癫患儿的甲状腺功能。
Objective To investigate the effect of oxcarbazepine (OXC) monotherapy on thyroid hormone in children with epilepsy. Methods 18 cases of epilepsy with newly diagnosed outpatients in outpatient department (treatment group) underwent OXC monotherapy. Before treatment, 3 mL of fasting venous blood samples were collected for 3 months and 1 days after treatment. Radioimmunoassay was used to detect serum (T4), free tetraiodothyronine (FT4), triiodothyronine (T3), free triiodothyronine (FT3) and thyroid stimulating hormone TSH) levels, and 18 healthy children as a healthy control group. The treatment group and healthy control group gender, age, no significant difference. Results The levels of T4, FT4, T3, FT3 and TSH in OXC before treatment were not significantly different from those in healthy controls (P> 0.05). OXC treatment for 3 months, T4, FT4 were significantly lower than before treatment, the differences were highly significant (Pa <0.01), T3, FT3, TSH compared with before treatment were no significant difference (Pa> 0.05). OXC treatment 1a, T4, FT4 were significantly different from those before treatment (Pa <0.01), T3 was also significantly different from that before treatment (P <0.05), while there was no significant difference between FTX and TSH Pa> 0.05). OXC treatment 1a, T4, FT4, T3, FT3 compared with 3 months of treatment had no significant difference (Pa> 0.05). Conclusion Long-term or short-term OXC can affect thyroid hormone levels in children with epilepsy. OXC should monitor the thyroid function of epileptic children regularly during treatment.