论文部分内容阅读
Tamm-Horsfall 蛋白(简称THP)是尿中粘蛋白的一种,乃Tamm 及Horsfall 于1951年发现并从尿中提纯。经免疫荧光或免疫酶电镜技术征实,它存在于亨氏袢升支与远端曲管上皮细胞,是一种肾脏特异的蛋白,由亨氏袢升支上皮细胞内高尔基体产生,正常时有少量排于尿中,24小时约50～100mg;当各种原因(如梗阴、炎症、自家免疫性疾患等)引起肾脏损伤时,尿中排出最增多,并与肾脏受损程度一致。THP 是管型的主要成份,其聚合物也是肾结石基质的重要前身,生理功能至今不清。Hoyzl 等认为可能与肾小管水代谢有关。THP
Tamm-Horsfall protein (THP) is a type of urinary mucin that Tamm and Horsfall discovered in 1951 and purified from the urine. Immunofluorescence or immunoelectron microscopy confirmed that it exists in the Hemsling asymptomatic branch and distal tubule epithelial cells, is a kidney-specific protein produced by Heinz-ascending ascending intracellular Golgi, a small amount of normal In the urine, 24 hours, about 50 ~ 100mg; when various causes (such as Terrier Yin, inflammation, autoimmune diseases, etc.) caused by renal damage, the most excreted in the urine, and consistent with the degree of renal damage. THP is the main component of the tube, the polymer is also an important precursor of the kidney stone matrix, physiological function is unclear. Hoyzl think may be related to tubular water metabolism. THP