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目的对2 635例婴幼儿腹泻患儿进行粪便A群轮状病毒抗原检测,为临床提供快捷、准确、可靠的诊断依据。方法应用免疫层析夹心法对门诊和住院的2 635例婴幼儿腹泻患儿新鲜粪便标本进行A群轮状病毒检测,并进行统计分析。结果 2 635例标本中,741例轮状病毒抗原检测阳性,总阳性率为28.12%,不同年龄段婴幼儿腹泻患儿轮状病毒感染率差异有统计学意义(P<0.05)。轮状病毒感染率在秋冬季节最高,春夏季节较低。在0~1岁年龄段中,母乳喂养的婴儿抗轮状病毒能力与非母乳喂养者比较,差异有统计学意义(P<0.05)。结论轮状病毒是婴幼儿腹泻的主要病原体,及时进行轮状病毒抗原检测,对于及时诊断和合理预防治疗具有重大意义。
Objective To detect stool group A rotavirus antigen in 2 635 infants and children with diarrhea and provide fast, accurate and reliable basis for diagnosis. Methods A group A rotavirus was detected in fresh stool samples of 2 635 infants with infantile diarrhea from outpatients and inpatients by immunochromatographic sandwich method and statistical analysis was made. Results Among 2 635 samples, 741 rotavirus antigens were detected positive, with a total positive rate of 28.12%. The rotavirus infection rates in infants with different age groups were significantly different (P <0.05). Rotavirus infection rate in the highest in autumn and winter, spring and summer seasons. In the age group of 0 to 1 years, the breast-fed infants had significantly lower resistance to rotavirus than non-breastfeeding mothers (P <0.05). Conclusions Rotavirus is the main pathogen of infantile diarrhea. The detection of rotavirus antigen in time is of great significance for timely diagnosis and reasonable prevention and treatment.