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一、裸鼠的发现 裸鼠是通常小鼠中的一种突变基因品种,顾名思义,是没有被毛的小鼠。由Grist首先发现,1962年Issacson作了正式报道。1966年Flanagan证实该鼠是由常染色体隐性遗传所致,并命名为裸鼠(Nude mice)。1968年Paulelouris和1969年De Souisa相继报告裸鼠无胸腺,其淋巴结中缺少胸腺依赖性T淋巴细胞,从而引起免疫学工作者的重视。值得注意的是实验小鼠中若干不同突变基因,都可以在不同部位产生不同程度的无毛表现型。如无胸腺鼠、裸鼠、无毛鼠、以及无鼻毛鼠等,其突变基因各有不同,不应相互混淆,因为它们是由不同位点上
First, the discovery of nude mice Nude mice is a common mutant type of mice, as the name implies, is no coat of mice. First discovered by Grist, Issacson made a formal report in 1962. In 1966 Flanagan confirmed that the mouse was caused by autosomal recessive inheritance and named Nude mice. Paulelouris in 1968 and De Souisa in 1969 have reported athymic nude mice, the lack of thymus-dependent T lymphocytes in lymph nodes, which attracted the attention of immunologists. It is worth noting that several different mutant genes in experimental mice can produce different degrees of glabrous phenotypes in different sites. Such as athymic mice, nude mice, hairless rats, and no nose hair rat, etc., the mutant genes are different and should not be confused with each other, because they are from different sites