本文通过饮水给予免疫抑制药和用人源隐孢子虫卵囊感染ＮＩＨ小鼠，建立了隐孢子虫感染小鼠模型。实验结果显示：免疫功能抑制组比正常组易感，两者感染度有显著性差异（Ｐ＜０．０５）。通过动物实验进一步证明免疫功能正常宿主感染隐孢子虫为自限性感染，免疫功能低下或缺陷者感染隐孢子虫可引起严重腹泻甚至死亡。 In this paper, immunosuppressive drugs were given to drinking water and NIH mice were infected with human Cryptosporidium oocysts, and a mouse model of Cryptosporidium infection was established. The experimental results showed that the immune suppression group was more susceptible than the normal group, and there was a significant difference (P <0.05). Animal experiments further prove that immune host normal infection of Cryptosporidium is a self-limiting infection, immunocompromised or defective infected with Cryptosporidium can cause severe diarrhea and even death.