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目的: 评价脑诱发电位(EP) 诊断亚临床型肝性脑病(SHE) 的价值。方法: 对48 例肝炎后肝硬化患者进行三种EP检查, 并追踪1年观察临床肝性脑病(HE) 出现情况。结果: 三种脑诱发电位总异常26例(54% ),其中听觉诱发电位 (BAEP) 异常18例 (38% )、视觉诱发电位(VEP) 异常3 例(6% )、体感诱发电位 (SEP) 异常10 例 (21% ), 以BAEP异常率最高。追踪观察1 年的29例患者中, 15例EP异常者出现HE11 例 (73% ), 无EP异常14例中, 出现HE4 例(28% ) (P< 0.05)。结论: 揭示BAEP对诊断SHE最敏感, 同时三种EP检查可提高SHE的检出率, 检测SHE有助于预测HE的发生有临床价值
Objective: To evaluate the value of brain evoked potentials (EP) in the diagnosis of subclinical hepatic encephalopathy (SHE). Methods: Thirty-eight patients with posthepatitic cirrhosis were enrolled in this study. Three kinds of EP were examined and followed up for 1 year to observe the occurrence of clinical hepatic encephalopathy (HE). Results: Totally 26 cases (54%) had abnormal brain evoked potentials (BAEP), 18 cases (38%) had abnormal auditory evoked potentials (BAEP), 3 cases had abnormal visual evoked potential (VEP) ) Abnormalities in 10 cases (21%), the highest rate of abnormal BAEP. Of the 29 patients who followed up for 1 year, HE11 (73%) were found in 15 patients with abnormal EP and 14 patients (28%) were HE without EP (P <0.05). Conclusion: It is revealed that BAEP is the most sensitive for the diagnosis of SHE, and the three EP tests can increase the detection rate of SHE. Detecting SHE is helpful to predict the occurrence of HE.