在慢性酗酒患者中叶酸缺乏是最常见的营养异常问题。除饮食不足外,小肠吸收和肝脏摄取的减少,肾分泌的增加,叶酸分子的氧化裂解,都会使酗酒者在慢性酒精中毒时导致叶酸缺乏。由于叶酸以5-甲基四氢叶酸(5-MTHF)的形式参与蛋氨酸的代谢,因此叶酸的缺乏将引起肝脏蛋氨酸代谢紊乱,从而造成DNA核苷酸失衡,肝细胞凋亡。肝脏蛋氨酸代谢可通过饮食和内源性叶酸进行 Folic acid deficiency is the most common nutritional disorder in chronic alcoholism. In addition to inadequate diet, reduced intestinal absorption and liver uptake, increased renal excretion, and oxidative cleavage of folate molecules can cause alcoholism in alcohol-induced chronic alcoholic folic acid deficiency. Since folic acid is involved in the metabolism of methionine in the form of 5-methyltetrahydrofolic acid (5-MTHF), the absence of folic acid causes disorder of liver methionine metabolism, resulting in DNA nucleotide imbalance and hepatocyte apoptosis. Metabolism of liver methionine can be by diet and endogenous folate