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目的观察尼可地尔与消心痛治疗心绞痛的临床疗效。方法将95例心绞痛患者随机分为尼可地尔组(48例)和消心痛组(47例),两组均常规服用阿司匹林0.1g 1次/d,氯吡格雷75mg 1次/d,阿托伐他汀10mg 1次/晚,有高血压或糖尿病者分别给予控制血压及血糖,尼可地尔组在常规治疗基础上加用尼可地尔5mg 3次/d,消心痛组给予消心痛10mg 3次/d,随防观察6个月,观察患者心血管事件发生率。结果尼可地尔组有7例出现心肌梗死或恶性心律失常,无猝死病例;消心痛组有16例发生心肌梗死或恶性心律失常,1例猝死。两组心脏事件发生率差异有统计学意义(P<0.05)。两组除有少数患者出现轻度头痛外,未见其他明显不良反应。结论尼可地尔治疗心绞痛预后较好,无明显不良反应,值得临床推广应用。
Objective To observe the clinical effect of nicorandil and xiao-hu-hu-hua in the treatment of angina pectoris. Methods Ninety-five patients with angina pectoris were randomly divided into Nicorandil group (n = 48) and XiaoXiaoTong group (n = 47). Both groups were given aspirin 0.1g once daily and clopidogrel 75mg once daily, Atorvastatin 10mg 1 time / night, hypertension or diabetes were given to control blood pressure and blood glucose, nicorandil group on the basis of conventional treatment plus nicorandil 5mg 3 times / d, 10mg 3 times / d, with the prevention of observation for 6 months to observe the incidence of cardiovascular events in patients. Results There were 7 cases of myocardial infarction or malignant arrhythmia in the Nicorandil group without any sudden death cases. Sixteen patients in the heartburn group had myocardial infarction or malignant arrhythmia and 1 case of sudden death. There was a significant difference in the incidence of cardiac events between the two groups (P <0.05). In addition to a few patients with mild headache in both groups, no other obvious adverse reactions. Conclusion Nicorandil treatment of angina good prognosis, no obvious adverse reactions, it is worth clinical application.