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研究肝素持续静脉点滴对羊吸入烟雾而引起急性肺损伤的作用。12只羊先行血管插管再用标准烟雾制作成吸入性损伤模型。伤后行持续机械通气,维持72小时。动物随机分成两组,每组6只。肝素组在伤后30分钟首剂静脉注射400U/kg牛肺肝素,随后持续点滴含肝素的生理盐水(每250ml含肝素25000U),使活化的凝血时间(ACT)维持在200～300S之间;对照组动物用等容量生理盐水处理。每隔6小时检测血液动力学指标,进行血气分析并取血浆标本测定结合二烯含量。尸检时取肺组织进行组
To study the effect of continuous intravenous drip of heparin on acute lung injury caused by smoke inhalation in sheep. Twelve sheep were instrumented with a standard smoke to establish an inhalation injury model. Continued mechanical injury sustained ventilation, maintained for 72 hours. The animals were randomly divided into two groups of six. In the heparin group, the first dose of 400U / kg bovine pulmonary heparin was injected intravenously 30 minutes after the injury, followed by continuous infusion of heparin-containing saline (25000U per 250ml heparin) to maintain the activated clotting time (ACT) between 200-300S; Control animals were treated with equal volume of saline. Hemodynamic parameters were measured every 6 hours, blood gas analysis was performed and plasma samples were taken for determination of bound diene content. Take the lung tissue for autopsy