血管平滑肌细胞(vascular smooth muscle cells,VSMCs)的增殖、肥大等病理变化在动脉粥样硬化、高血压等心血管疾病发病过程扮演着重要角色,导致该病变的机制之一为血管紧张素II(Ang II)对血管收缩、细胞增殖、纤维化、炎症等方面的促进作用。研究显示,Ang II与其受体结合后能够上调VSMCs中促炎、促纤维化基因,如Mcp-1、IL-6、Pai-1,以及细胞外基质胶原 Pathological changes such as proliferation and hypertrophy of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of cardiovascular diseases such as atherosclerosis and hypertension. One of the mechanisms leading to this pathological change is angiotensin II Ang II) on the vasoconstriction, cell proliferation, fibrosis, inflammation and other aspects of the promotion. Studies have shown that Ang II binds to its receptor to upregulate the proinflammatory and fibrotic genes in VSMCs such as Mcp-1, IL-6, Pai-1, and extracellular matrix collagen