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目的 评价心肌声学造影定量心肌梗塞心肌血流灌注的价值。方法 对６条犬急性心肌梗塞模型进行心肌声学造影， 采用自身对照的方法分析缺血区和非缺血区心肌显影时间－强度曲线各参数之比与心肌血流量的关系。结果 梗塞区时间－强度曲线各参数中， 曲线下面积（ＡＵＣ）和峰值强度（ＰＩ）与心肌相对血流量高度相关（ｒ＝ ０．９２和０．８４， Ｐ＜ ０．０１）， 与心肌绝对血流量相关性良好（ｒ＝ ０．７７和０．７１， Ｐ＜ ０．０１）。不同水平心肌血流量间的ＡＵＣ、ＰＩ均存在显著性差异（Ｐ均小于０．０１）， 且随着血流量的减少而呈下降趋势。三项时间指标与心肌绝对血流量无直接关系。结论 心肌造影时间－强度曲线参数中的曲线下面积和峰值强度可准确定量心肌梗塞后局部心肌血流量。
Objective To evaluate the value of myocardial contrast echocardiography in quantitative myocardial perfusion of myocardial infarction. Methods Myocardial contrast echocardiography was performed in 6 canine acute myocardial infarction models. The relationship between the parameters of time - intensity curve and myocardial blood flow in ischemic and nonischemic myocardium was analyzed by self - control method. Results The area under the curve (AUC) and peak intensity (PI) in the time-intensity curve of infarction area were highly correlated with myocardial relative blood flow (r = 0.92 and 0.84, P <0.01) Absolute blood flow was well correlated (r = 0.77 and 0.71, P <0.01). There were significant differences in AUC and PI between different levels of myocardial blood flow (P <0.01), and decreased with the decrease of blood flow. Three time indicators and myocardial absolute blood flow is not directly related. Conclusions The area under the curve and the peak intensity in the parameters of myocardial contrast time-intensity curve can accurately measure the local myocardial blood flow after myocardial infarction.