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患有慢性感染或癌症的人或动物往往易出现恶液质综合征,同时伴有血清中甘油三酯和脂蛋白酶(LPL)活性的增高.LPL源于脂肪细胞,常见于内皮细胞表面,可水解循环中的甘油三酯形成脂肪酸,阻止脂肪的储存.文章重点论述了IL-6具有降低脂肪组织和体外培养的脂肪细胞中的LPL活性的功能这一观点.
People with chronic infections or cancers often develop cachexia syndromes accompanied by an increase in serum triglyceride and lipoprotein (LPL) activity. LPL is derived from adipocytes and is commonly found on the surface of endothelial cells. Triglycerides in the hydrolysis cycle form fatty acids that prevent the storage of fat.The article highlights the notion that IL-6 functions to reduce LPL activity in adipose tissue and in vitro cultured adipocytes.