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目的探讨冠心病患者血浆中同型半胱氨酸(Hcy)水平与左心室舒张功能之间的关联性。方法收集120例冠心病患者为研究对象,根据多普勒组织成像检查二尖瓣的舒张早期快速充盈峰值流速与二尖瓣充盈早期环运动峰值流速的比值(E/Ea)进行分组,E/Ea<15组共72例,E/Ea≥15组共48例。比较2组患者基线资料以及超声检查结果,采取直线相关分析法分析Hcy以及多普勒超声指标与E/Ea之间的关联性。结果 E/Ea≥15组患者年龄为(74.10±7.58)岁,明显高于E/Ea<15组患者的(67.23±5.36)岁,2组比较差异有统计学意义(P<0.05);E/Ea≥15组患者心功能指标E、A、E/Ea均显著高于E/Ea<15组(P均<0.05),而Ea则显著低于E/Ea<15组(P<0.05);E/Ea≥15组患者血浆中Hcy水平为(18.32±5.34)μmol/L,显著高于E/Ea<15组的(14.76±4.33)μmol/L;冠心病患者血浆中Hcy水平与E/Ea指标存在明显相关性,相关系数为0.215(P<0.05)。结论血浆中Hcy水平与冠心病患者左心室舒张功能存在明显相关性,可以作为早期预测冠心病正常射血分数心衰,从而更加有效防治冠心病心力衰竭。
Objective To investigate the correlation between plasma homocysteine (Hcy) levels and left ventricular diastolic function in patients with coronary heart disease. Methods A total of 120 patients with coronary heart disease (CHD) were enrolled in this study. The ratio of mitral inflow early mitral inflow velocity to mitral inflow peak annular velocity (E / Ea) was determined by Doppler tissue imaging. E / There were 72 cases in Ea <15 groups and 48 cases in E / Ea≥15 group. The baseline data and the results of ultrasound examination were compared between two groups. The linear correlation analysis was used to analyze the association between Hcy and Doppler ultrasound and E / Ea. Results The age of E / Ea≥15 group was (74.10 ± 7.58) years old, which was significantly higher than that of E / Ea <15 group (67.23 ± 5.36) years old. There was significant difference between the two groups (P <0.05) (P <0.05), while Ea was significantly lower than that in E / Ea <15 groups (P <0.05) (18.32 ± 5.34) μmol / L in E / Ea≥15 group, which was significantly higher than that in E / Ea <15 group (14.76 ± 4.33) μmol / L; The level of plasma Hcy in E / Ea≥15 group was significantly higher than that in E / Ea indicators there is a significant correlation, correlation coefficient of 0.215 (P <0.05). Conclusion There is a significant correlation between plasma homocysteine level and left ventricular diastolic function in patients with coronary heart disease. It can be used as an early prediction of normal ejection fraction of coronary heart disease, and thus prevent and treat coronary heart disease more effectively.