论文部分内容阅读
目的探讨泼尼松对肾病综合征(NS)患儿骨吸收功能的影响。方法以2001年8月至2002年10月河北医科大学第二医院儿科收治的25例NS患儿为研究对象,采用自身对照形式,测定患儿应用泼尼松治疗前(激素治疗前组)和应用足量泼尼松治疗后(激素足量治疗组)尿脱氧吡啶啉排泄率(DPD/Cr)及24h尿钙浓度。结果在激素治疗4~8周后,激素足量治疗组尿DPD/Cr明显高于激素治疗前组(P<0.05),24h尿钙明显升高(P<0.01),但二者无相关性。结论泼尼松足量治疗阶段,NS患儿骨吸收功能增强,易导致骨质疏松;激素治疗期间24h尿钙作为评价骨吸收的指标缺乏特异性。
Objective To investigate the effect of prednisone on bone resorption in children with nephrotic syndrome (NS). Methods Twenty-five children with NS admitted to the Second Hospital of Hebei Medical University from August 2001 to October 2002 were enrolled in this study. Their self-control form was used to determine the effect of prednisone (pre-hormone therapy group) and After adequate prednisone treatment (hormone adequate treatment group), the urinary deoxypyridine excretion rate (DPD / Cr) and the 24 h urinary calcium concentration were applied. Results After 4 to 8 weeks of hormone therapy, urinary DPD / Cr in hormone adequate treatment group was significantly higher than that before hormone treatment (P <0.05), and 24h urinary calcium increased significantly (P <0.01), but there was no correlation between them . Conclusion Prednisone adequate treatment stage, NS children with increased bone resorption function, easily lead to osteoporosis; 24 hours during hormone therapy, urinary calcium as a marker of bone loss evaluation of the lack of specificity.