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目的检测MMP-9、CD44v6在乳腺浸润性癌中的表达情况,研究两者与淋巴结转移的关系。方法采用免疫组化SP法检测92例乳腺浸润性癌中MMP-9、CD44v6的表达情况。结果 MMP-9蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/45)和92.4%(85/92),而且MMP-9在淋巴结转移组中的阳性表达率(54/55)明显高于无淋巴结转移组(P<0.05)。CD44v6蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为8.9%(4/45)和85.9%(79/92),而且CD44v6在淋巴结转移组中的阳性表达率(51/55)明显高于无淋巴结转移组(P<0.05)。结论 MMP-9、CD44v6蛋白在乳腺癌组织中高表达,且均与淋巴结转移有关(P<0.05),检测MMP-9、CD44v6有助于判断乳腺癌的恶性程度和转移情况。
Objective To detect the expression of MMP-9 and CD44v6 in invasive breast cancer, and to study their relationship with lymph node metastasis. Methods Immunohistochemical SP method was used to detect the expression of MMP-9 and CD44v6 in 92 cases of invasive breast cancer. Results The positive rates of MMP-9 protein in normal breast tissues and breast cancer tissues were 0 (0/45) and 92.4% (85/92) respectively, and the positive rates of MMP-9 in lymph node metastasis group were 54% 55) was significantly higher than those without lymph node metastasis (P <0.05). The positive rates of CD44v6 protein in normal breast tissues and breast cancer tissues were 8.9% (4/45) and 85.9% (79/92) respectively, and the positive rates of CD44v6 in lymph node metastasis group (51/55) were significantly higher No lymph node metastasis (P <0.05). Conclusion The expressions of MMP-9 and CD44v6 in breast cancer tissues are highly correlated with lymph node metastasis (P <0.05). Detecting the expression of MMP-9 and CD44v6 may be helpful to evaluate the malignancy and metastasis of breast cancer.