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[背景]最近的研究结果表明,孕妇妊娠期间吸烟可能在其后代儿童期代谢的变化中发挥作用。然而,这种暴露是否增加成年期类似代谢改变的风险尚不确定。[目的]评估子宫内烟草烟雾暴露与成年期血浆血脂、载脂蛋白B(apoB)和C-反应蛋白(CRP)之间的关联。[方法]研究基于挪威母子队列研究(MoBa)的子样本,检测了479名孕妇的血脂、apoB和CRP。约在妊娠17周,通过入组孕妇完成自评问卷,获得有关子宫内烟草烟雾暴露、个人吸烟史及其他因素的有关信息。[结果]校正年龄、体力活动、教育、个人吸烟和体质指数(BMI)后,与无暴露的女性相比,在子宫内暴露于烟草烟雾的女性三酰甘油水平较高[升高10.7%,95%可信区间(CI):3.9%~17.9%],高密度脂蛋白胆固醇(HDL)水平较低(-1.9mg/L,95%CI:-4.3~0.5mg/L)。烟草烟雾暴露的女性三酰甘油≥2000mg/L[校正比值比(aOR)=2.5,95%CI:1.3~5.1],和HDL<500mg/L(aOR=2.3,95%CI:1.1~5.0)的可能性更大。低密度脂蛋白胆固醇、总胆固醇和apoB与暴露无关联。暴露女性的CRP升高,然而经BMI校正后,相关性完全消失。[结论]在该人群中,子宫内暴露于烟草烟雾与成年期(暴露1844年后)高三酰甘油及低HDL相关。
[Background] Recent findings suggest that smoking during pregnancy in pregnant women may play a role in the metabolic changes of their offspring in childhood. However, whether this exposure increases the risk of similar metabolic changes in adulthood remains uncertain. [Objective] To evaluate the correlation between intrauterine tobacco smoke exposure and adult plasma lipids, apolipoprotein B (ApoB) and C-reactive protein (CRP). [Method] Study Serum lipids, apoB, and CRP were measured in 479 pregnant women based on a sub-sample of the Norwegian Maternal Cohort Study (MoBa). About 17 weeks of gestation, a self-assessment questionnaire was completed for pregnant women enrolled to obtain information on intrauterine exposure to tobacco smoke, personal smoking history, and other factors. [Results] Women who had been exposed to tobacco smoke in the uterus had higher levels of triglyceride than those who did not (adjusted for age, physical activity, education, personal smoking, and body mass index (BMI) by 10.7% 95% confidence interval (CI): 3.9% to 17.9%] and low HDL levels (-1.9 mg / L, 95% CI: -4.3 to 0.5 mg / L). Tobacco smoke exposed female triglycerides ≥ 2000 mg / L [aOR = 2.5, 95% CI: 1.3-5.1] and HDL <500 mg / L (aOR = 2.3, 95% CI: 1.1-5.0) More likely. Low-density lipoprotein cholesterol, total cholesterol and apoB were not associated with exposure. Exposure to elevated female CRP, however, corrected by BMI, the correlation disappeared completely. [Conclusion] Uterine exposure to tobacco smoke in this population was associated with increased triglycerides and low HDL during adulthood (after 1844 exposure).