化学致癌物在人类肿瘤病因学上具有重要作用。本文提供了很多化合物,在接触致癌物之前或接触同时使用这些化合物,对化学致癌作用均具有抑制能力。其可能机制为:1改变致癌物的代谢,包括(a)降低活化作用,(6)增加解毒作用(c)两者兼而有之。2消除各种致癌物的活性代谢产物,防止其抵达细胞内靶作用部位。3竞争性抑制。 1. 酚类抗氧化剂和乙氧奎宁: 研究得最多的是酚类化合物。特别是盐酸丁羟基苯甲醚(BHA)和盐酸丁羟基甲苯(BHT)。根据BHA对雌性小鼠肝微粒体酶对3、4-苯并芘(简称Bp,下同)代谢影响的研究,发现经BHA喂养的实验小鼠,其肝微粒体与DNA、Bp共同 Chemical carcinogens play an important role in the etiology of human tumors. This document provides many compounds that can be used to inhibit chemical carcinogenesis both before and during exposure to carcinogens. The possible mechanisms are: 1 to change the metabolism of carcinogens, including (a) to reduce the activation, (6) to increase the detoxification (c) both. 2 eliminate all kinds of carcinogens active metabolites, to prevent the target site of its arrival in cells. 3 competitive inhibition. 1. Phenolic antioxidants and ethoxyquin quinine: The most studied phenolic compounds. Especially butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). According to the study of the effect of BHA on the metabolism of 3,4-benzopyrene (abbreviated as Bp, the same below) in liver microsomes of female mice, it was found that the liver microsomes of BHA-fed mice were co-cultured with DNA and Bp