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[目的]了解泰州市一般人群HBsAg携带状况和抗体水平及其血清流行病学变动趋势。[方法]采用多阶段随机抽样方法,于2001年、2004年、2007年在泰州市的两个乡镇分别抽取一般人群血清440份、398份和971份,用ELISA法开展HBV感染标志的血清学检测,对其结果进行比较分析。[结果]泰州市2001、2004、2007年一般人群HBsAg阳性率分别为13.86%、9.55%、8.24%,标化阳性率分别为16.94%、24.33%、10.40%,单抗-HBs阳性标化率分别为44.84%、12.02%、8.26%。HBsAg阳性率在3个年度中呈现出由低年龄组向高年龄组逐步升高的趋势,单抗-HBs阳性率在2004年和2007年呈现出随年龄组增加而下降的趋势。除2007年男性单抗-HBs阳性率为16.10%,高于女性的11.22%外(χ2=4.92、P=0.03),男女人群HBsAg阳性率、单抗-HBs阳性率差异无显著性,免疫规划实施后出生人群HBsAg阳性率低于实施前出生人群,而抗-HBs阳性率高于实施前人群。[结论]泰州市一般人群HBsAg阳性率有不同程度的下降,免疫规划实施前后出生人群HBsAg阳性率、单抗-HBs阳性率差异显著。
[Objective] To understand the status of HBsAg carrier and antibody in Taizhou general population and its trend of serum epidemiology. [Methods] A total of 440 serum samples, 398 serum samples and 971 serum samples were collected from two populations in Taizhou City in 2001, 2004 and 2007 by using multistage random sampling method. Serological markers of HBV infection were detected by ELISA Testing, the results of comparative analysis. [Results] The positive rates of HBsAg in the general population in 2001, 2004 and 2007 in Taizhou City were 13.86%, 9.55% and 8.24%, respectively. The positive rates of HBsAg were 16.94%, 24.33% and 10.40% Respectively 44.84%, 12.02%, 8.26%. The positive rate of HBsAg showed a trend of gradually increasing from the low age group to the high age group in three years. The positive rate of the monoclonal antibody-HBs showed a trend of decreasing with the increase of the age group in 2004 and 2007. The positive rate of HBsAg and the rate of McAb-HBs in male and female were not significant except for the positive rate of male monoclonal antibody-HBs in 2007 (16.10%) and 11.22% (χ2 = 4.92, P = 0.03) The HBsAg positive rate of the born population after implementation was lower than that before the implementation, while the positive rate of anti-HBs was higher than that before the implementation. [Conclusion] The positive rate of HBsAg in the general population of Taizhou City decreased to some extent. The positive rate of HBsAg in the population before and after the immunization program was significantly different, and the positive rate of McAb-HBs was significant.