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人们一直关注脂多糖(lipopolysaccharide,LPS)等细菌产物如何激活炎性细胞,并促进炎性细胞因子表达。目前已经明确,编码TNFα、IL1β、IL6和IL8的基因,是由核转录因子κB(nuclearfactorκB,NFκB)控制表达的。NFκB具有强大的基因调控能力,在调控与急性肺损伤(ALI)急性呼吸窘迫
Much attention has been focused on how bacterial products, such as lipopolysaccharide (LPS), activate inflammatory cells and promote the expression of inflammatory cytokines. It is now clear that the genes encoding TNFα, IL1β, IL6 and IL8 are expressed under the control of nuclear factor κB (NFκB). NFκB has a strong gene regulatory capacity in the regulation and acute lung injury (ALI) of acute respiratory distress