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本文应用化学发光（ＣＬ）方法体外检测了３９例海洛因依赖者多形核白细胞（ＰＭＮ）的化学发光的变化，结果表明：海洛因滥用者治疗前ＰＭＮ的ＣＬ值，未被ＯＺ刺激积分面积为２２．１±ｓ８．０２（×１０４ｃｐｓ／１０６ＷＢＣ），经脱毒治疗８－１２ｄ后为１５．３６±ｓ５．６１（×１０４ｃｐｓ／１０６ＷＢＣ），较脱毒前有所降低（Ｐ＜０．０５）；经ＯＺ刺激后积分面积为３１５．６±ｓ９４．５（×１０４ｃｐｓ／１０６ＷＢＣ），脱毒８－１２ｄ后明显降低为１７６．２±ｓ９３．９（×１０４ｃｐｓ／１０６ＷＢＣ）（Ｐ＜０．０１）。提示：经脱毒治疗后外周血ＰＭＮ的自由基有明显变化。同时观察了ＰＭＮ－ＣＬ在男女性别之间，与毒品滥用方式（烫吸与注射）、时间（＞１８月与＜１８月）及滥用量（＞１．０ｇ与＜１．０ｇ）的关系，未发现其有明显差异。
Chemiluminescence (CL) was used to detect the chemiluminescence changes of 39 cases of polymorphonuclear leukocytes (PMN) of heroin addicts in vitro. The results showed that the CL value of PMN before heroin abuse treatment was not increased by 22% (± 104cps / 106WBC) after detoxification treatment and 15.36 ± s5.61 (× 104cps / 106WBC) after detoxification treatment for 8-12 days (P <0.05) (P <0.01). The integral area after stimulation by OZ was 315.6 ± s94.5 (× 104cps / 106WBC) and was significantly reduced to 176.2 ± s93.9 (× 104cps / 106WBC) after 8-12 days ). Tip: after detoxification of free radicals in peripheral blood PMN significant changes. At the same time, we observed the relationship between PMN-CL and gender, drug abuse patterns (hot aspiration and injection), time (> 18 months and <18 months) and abuse (> 1.0g and <1.0g) No significant difference was found.