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【目的】通过青少年代谢综合征(metabolic syndrome,MS)相关组分的因子分析,探索青少年MS病理生理机制。【方法】以哈尔滨市某校130名高一学生为研究对象。测量身高、体重、腰围、臀围、收缩压、舒张压,计算体质指数、腰臀比和腰围身高比;测定空腹血糖、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及血清超敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)含量。【结果】未引入hs-CRP变量时,提取三个公因子:肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的31.730%、22.287%和16.767%,累计方差贡献率为70.784%。引入hs-CRP变量后,青少年MS相关组分共提取3个因子,分别为肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的32.697%、20.275%、15.454%,累计方差贡献率为68.427%。【结论】肥胖因子在青少年MS发病机制中起主要作用;腰围身高比较腰围更适于评价青春期MS的中心性肥胖;hs-CRP可能参与青春期MS的发病。
【Objective】 To explore the pathophysiological mechanism of adolescent MS through factor analysis of related components of metabolic syndrome (MS). 【Method】 A total of 130 high school students in a certain school in Harbin were studied. Body height, body weight, waist circumference, hip circumference, systolic pressure, diastolic blood pressure, body mass index, waist-to-hip ratio and waist height ratio were measured. Fasting blood glucose, serum total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein Cholesterol and serum high sensitivity C reactive protein (hs-CRP). 【Results】 Three factors, obesity, lipid metabolism and blood pressure and blood glucose, were extracted without introducing hs-CRP, accounting for 31.730%, 22.287% and 16.767% of the 10 original variables, respectively. The cumulative variance contribution rate was 70.784 %. After the introduction of hs-CRP variable, three components of juvenile MS were extracted, which were obesity, lipometabolism and blood pressure and blood glucose respectively, which accounted for 32.697%, 20.275% and 15.454% respectively of the 10 original variables, with cumulative variance contribution The rate was 68.427%. 【Conclusion】 Obese factors play a major role in the pathogenesis of adolescent MS. Compared with waist circumference, waist circumference is more suitable for evaluating central obesity in adolescent MS. Hs-CRP may be involved in the pathogenesis of adolescent MS.