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密度感应是指细菌根据菌群密度的变化分泌和感应信号分子-感受态调节肽(CSP),调控相关基因的表达。变链素是变异链球菌合成分泌的抗菌性多肽,在菌群中可调节相关细菌的生物学行为。变异链球菌密度感应系统可调控变链素的合成和分泌,参与菌群间的交流,调控牙菌斑生物膜的稳定性。下面就近年来受密度感应系统调控的变链素的研究进展作一综述。
Density sensing refers to the bacterial secretion and induction of signaling molecules according to changes in bacterial density - Competent Regulatory Peptide (CSP), regulating the expression of related genes. Variable streptococci Streptococcus mutans synthesis and secretion of antibacterial peptides in the flora can regulate the biological behavior of the relevant bacteria. Streptococcus mutans density sensing system can control the synthesis and secretion of variable chain, participate in the exchange between the flora, regulating the stability of the plaque biofilm. The following in recent years by the density-sensing system to control the progress of the study of the variable link.