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目的 :探讨 s Fas与 s Fas L 在多发性硬化 (MS)发病中的意义。方法 :采用固相酶联免疫分析 (EL ISA)法检测 6 6例MS患者血清 s Fas、s Fas L 水平。结果 :MS患者血清 s Fas、s Fas L 水平均高于健康对照组 ,MS患者活动期 s Fas显著高于缓解期(P <0 .0 1) ,而 s Fas L 水平未见显著差异。在 6 6例 MS患者中 ,有 37例 s Fas和 s Fas L 的水平同时升高。结论 :s Fas水平与 MS的炎症程度有关 ,血清 s Fas、s Fas L 检测有助于对 MS病情进展作出判断 ,并为 MS的免疫生物治疗提供新方法
Objective: To investigate the significance of s Fas and s Fas L in the pathogenesis of multiple sclerosis (MS). Methods: The serum levels of sFas and FasL in 66 MS patients were detected by ELISA. Results: The levels of Fas and FasL in serum of MS patients were significantly higher than those of healthy controls. The s Fas of active MS patients was significantly higher than that of remission patients (P <0.01), while the level of s Fas L was not significantly different. In 66 MS patients, 37 cases of s Fas and s Fas L levels increased simultaneously. CONCLUSIONS: The level of s-Fas is related to the degree of inflammation in MS. The detection of serum s-Fas and s-Fas levels is helpful to judge the progression of MS and provide a new method for the immunobiotherapy of MS