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目的探讨溃疡性结肠炎(UC)患者血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平与骨质疏松的相关性。方法选取该院2012年1月-2014年12月收治的UC患者100例作为观察组,健康体检者60例作为对照组。采用酶联免疫吸附试验(ELISA法)检测2组血清TNF-α、IL-6及IL-8水平,超声检测2组L1~L4骨密度(BMD)。结果观察组患者骨密度降低47例(47%),骨密度低于对照组,血清TNF-α、IL-6及IL-8水平高于对照组,差异均有统计学意义(P<0.05)。结论血清TNF-α、IL-6及IL-8水平在UC患者骨质疏松发生中起重要作用,检测UC患者血清TNF-α、IL-6及IL-8水平可用于诊断和预防骨质疏松。
Objective To investigate the correlation between serum levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) and osteoporosis in patients with ulcerative colitis. Methods A total of 100 UC patients admitted from January 2012 to December 2014 in our hospital were selected as observation group and 60 healthy subjects as control group. Serum levels of TNF-α, IL-6 and IL-8 were measured by enzyme-linked immunosorbent assay (ELISA), and bone mineral density (BMD) Results Compared with the control group, the BMD of the observation group decreased 47 cases (47%), the BMD was lower than that of the control group, the levels of TNF-α, IL-6 and IL-8 in the observation group were significantly higher than those in the control group . Conclusion Serum levels of TNF-α, IL-6 and IL-8 play an important role in the pathogenesis of osteoporosis in UC patients. Serum levels of TNF-α, IL-6 and IL-8 in UC patients can be used to diagnose and prevent osteoporosis .