全世界有10%-15%的夫妻在结婚一年内未孕。这些病例中,男性因素不育至少占一半。男性不育的原因很多,包括身体发育异常、免疫原因、精子畸形、染色体异常、Y染色体微缺失、基因缺失、基因单核苷酸多态性以及其他原因。本文综述男性不育的每一种因素,其目的是为了帮助临床医师对不育男性病人诊断、遗传咨询以及进一步开展辅助生殖工作。 Between 10% and 15% of couples in the world do not get pregnant within a year of marriage. In these cases, male infertility accounted for at least half. There are many reasons for male infertility, including body dysplasia, immune causes, sperm deformity, chromosomal abnormalities, Y chromosome microdeletions, gene deletions, single nucleotide polymorphisms and other causes. This article summarizes each of the factors of male infertility, the purpose is to help clinicians diagnose male infertility, genetic counseling and further assisted reproductive work.