喂DENA13周诱发大鼠肝癌变时,组织特异酶OCT活性降低,而细胞增殖酶ACT活性升高。其后发生肝癌者,肝内OCT及ACT活性的相互变化始终保持发生肝癌动物的水平;而部分未发生肝癌者,OCT及ACT活性的相互变化则趋于正常水平,即OCT活性开高,ACT活性下降,表明OCT/ACT活性一直处于不平衡状态时可能与肝癌发生有密切关系。喂DEN13周大鼠注射甲状腺素,可使早期肝癌肝OCT活性升高,ACT活性降低。 When DENA was induced for 13 weeks, the OCT activity of tissue-specific enzyme decreased while the activity of cell proliferation enzyme increased. The subsequent occurrence of liver cancer, intrahepatic OCT and ACT activity change always maintain the level of occurrence of liver cancer animals; and some did not occur in liver cancer, OCT and ACT activity tended to be the normal level, that OCT activity was high, ACT Activity decreased, indicating that OCT / ACT activity has been in an imbalance may be closely related to the occurrence of liver cancer. Injections of thyroxine for 13 weeks in DEN rats increased liver OCT activity and decreased ACT activity in early stage liver cancer.